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验证数据展示

  • IF Staining of mouse heart using CL488-14060

    IF Staining of mouse heart using CL488-14060

    Immunofluorescent analysis of (4% PFA) fixed mouse heart tissue using CoraLite® Plus 488 PARK2/Parkin antibody (CL488-14060) at dilution of 1:200.

  • IF Staining of mouse heart using CL488-14060

    IF Staining of mouse heart using CL488-14060

    Immunofluorescent analysis of (4% PFA) fixed mouse heart tissue using CoraLite® Plus 488 PARK2/Parkin antibody (CL488-14060) at dilution of 1:200.

  • Featured Product
  • KD/KO验证

CoraLite® Plus 488-conjugated PARK2/Parkin Polyclonal antibody

PARK2/Parkin Polyclonal Antibody for IF-P
Cat No. CL488-14060

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IF-P

别名

AR JP, LPRS2, PARK2, Parkinson disease protein 2, PDJ, PRKN

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格价格库存

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经过测试的应用

Positive IF-P detected inmouse heart tissue, mouse brain tissue
Planning an IHC experiment? We recommend our IHCeasy PARK2 Ready-To-Use IHC Kit. PARK2 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 14060-1-AP

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-14060 targets PARK2/Parkin in IF-P applications and shows reactivity with human, mouse, rat samples.

经测试应用 IF-P Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag5092

Product name: Recombinant human Parkin protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 81-387 aa of BC022014

Sequence: NATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVGTGDTVVLRGALGGFRRGVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGYGQRRTK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 Parkinson disease (autosomal recessive, juvenile) 2, parkin
别名 AR JP, LPRS2, PARK2, Parkinson disease protein 2, PDJ, PRKN
计算分子量 52 kDa
观测分子量 42-52 kDa
GenBank蛋白编号BC022014
基因名称 Parkin
Gene ID (NCBI) 5071
RRIDAB_2919085
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO60260
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Parkin, a RING-type E3 ubiquitin-protein ligase, is involved in the ubiquitination pathway and contributes to protection from neurotoxicity induced by unfolded protein stresses. Its ubiquitin-protein ligase activity promotes the degradation of a variety of proteins including itself. Mutations in Parkin are implicated in the pathogenesis of autosomal recessive familial Parkinson's disease. It has 8 isoforms produced by alternative splicing.

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 PARK2/Parkin antibody CL488-14060Download protocol
Standard Protocols
Click here to view our Standard Protocols