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验证数据展示

  • WB analysis of TF-1 using 66519-1-Ig (same clone as 66519-1-PBS)

    WB analysis of TF-1 using 66519-1-Ig (same clone as 66519-1-PBS)

    TF-1 cells were subjected to SDS PAGE followed by western blot with 66519-1-Ig (CD11B/Integrin alpha M antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66519-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 66519-1-Ig (same clone as 66519-1-PBS)

    IHC staining of human tonsillitis using 66519-1-Ig (same clone as 66519-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66519-1-Ig (CD11B/Integrin alpha M antibody) at dilution of 1:1000 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66519-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CD11B antibody included
  • IHC staining of human tonsillitis using 66519-1-Ig (same clone as 66519-1-PBS)

    IHC staining of human tonsillitis using 66519-1-Ig (same clone as 66519-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66519-1-Ig (CD11B/Integrin alpha M antibody) at dilution of 1:1000 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66519-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CD11B antibody included
  • IF Staining of human tonsillitis using 66519-1-Ig (same clone as 66519-1-PBS)

    IF Staining of human tonsillitis using 66519-1-Ig (same clone as 66519-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using 66519-1-Ig (CD11B/Integrin alpha M antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66519-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 66519-1-Ig (same clone as 66519-1-PBS)

    IF Staining of human tonsillitis using 66519-1-Ig (same clone as 66519-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human tonsillitis tissue using CD11B/Integrin Alpha M antibody (66519-1-Ig, Clone: 1C7C2 ) at dilution of 1:200 and CoraLite®594-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-3). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66519-1-PBS in a different storage buffer formulation.

CD11b Monoclonal antibody, PBS Only

CD11b Monoclonal Antibody for WB, IHC, IF-P, ELISA
Cat No. 66519-1-PBS

产品说明书

CloneNo. 1C7C2

宿主/亚型

Mouse / IgG2b

种属反应性

human

应用

WB, IHC, IF-P, ELISA

别名

1C7C2, CD11 antigen-like family member B, Cell surface glycoprotein MAC-1 subunit alpha, CR 3 alpha chain, CR-3 alpha chain

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy CD11B Ready-To-Use IHC Kit. CD11B primary antibody included.

产品信息

66519-1-PBS targets CD11b in WB, IHC, IF-P, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF-P, ELISA Application Description
经测试反应性 human
免疫原

Peptide

种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 integrin, alpha M (complement component 3 receptor 3 subunit)
别名 1C7C2, CD11 antigen-like family member B, Cell surface glycoprotein MAC-1 subunit alpha, CR 3 alpha chain, CR-3 alpha chain
计算分子量 93 kDa
观测分子量 160 kDa
GenBank蛋白编号NM_000632
基因名称 CD11b
Gene ID (NCBI) 3684
ENSEMBL Gene IDENSG00000169896
RRIDAB_2881882
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP11215
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

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