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验证数据展示

  • WB analysis of pig heart using 66415-1-Ig (same clone as 66415-1-PBS)

    WB analysis of pig heart using 66415-1-Ig (same clone as 66415-1-PBS)

    pig heart tissue were subjected to SDS PAGE followed by western blot with 66415-1-Ig (AGTR1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66415-1-PBS in a different storage buffer formulation.

AGTR1 Monoclonal antibody, PBS Only

AGTR1 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 66415-1-PBS

产品说明书

CloneNo. 2C5G11

宿主/亚型

Mouse / IgG2a

种属反应性

human, mouse, rat, pig

应用

WB, Indirect ELISA

别名

Angiotensin II type-1 receptor, Angiotensin II type 1 receptor, AGTR1B, AGTR1A, AG2S

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

66415-1-PBS targets AGTR1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat, pig
免疫原

CatNo: Ag14461

Product name: Recombinant human AGTR1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 290-359 aa of BC022447

Sequence: IAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRHSDNVSSSTKKPAPCFEVE

种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 angiotensin II receptor, type 1
别名 Angiotensin II type-1 receptor, Angiotensin II type 1 receptor, AGTR1B, AGTR1A, AG2S
计算分子量 359 aa, 41 kDa
观测分子量 50 kDa
GenBank蛋白编号BC022447
基因名称 AGTR1
Gene ID (NCBI) 185
RRIDAB_2881787
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP30556
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system, exerts its actions mainly via interaction with type-1 angiotensin II receptor (AGTR1, also named as AT1R), thereby contributing to blood pressure regulation. AGTR1 mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. By regulating vascular tone, cardiovascular function, salt and water homeostasis, AGTR1 exerts an indispensable physiological role (PMID: 21600887). AGTR1 has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression (PMID: 26975580).